CURRICULUM VITAE
SALIH A. EMRI, M.D.
PERSONAL DATA Work Address: Hacettepe University School of Medicine, Department of Chest Diseases, Ankara, Turkey 06100.
Telephone: 90 (312) 305 1442
Fax: 90 (312) 310 310 0809Home Address: Çigdem mah. 29. sokak, No: 27/2, Ankara, Turkey.
Telephone: 90 (312) 285 9273
E-mail: se06-k@tr-net.net.trDate and Place of Birth: March 01, 1957, Ankara Academic Title: Associate Professor of Medicine (7/1992 - present)
Hacettepe University Medical School, Ankara, TurkeyMarital Status: Married: 1988 Spouse: Dilek Children: Güliz - Daughter Citizenship: Republic of Turkey Military Service: Gülhane Military Medical Academy, Section of Gastroenterology, Ankara
Internist, 1989-1990Special Interets: Tennis Examination Achieved: FMGEMS Clinical Science Component- January 1992. EDUCATION AND TRAINING Medical School: Hacettepe University School of Medicine, Ankara, Turkey M.D. Degree
1974-1982Internship: Hacettepe University School of Medicine, Ankara, Turkey Rotating Intern 1981-1982 Residency: Hacettepe University School of Medicine, Internal Medicine 1984-1989 Fellowship: Hacettepe University School of Medicine, Pulmonology 1990-1992
Boston University Medical Center, Section of Oncology, Research Fellow Boston, Mass.,USA 1993-1994Other: Four Months Of Training And Participating In Clinical Studies In Sleep Laboratory Of Neurology, At The Medical Center Of Boston University, Mass., USA. 1994 Elected National Positions: Chairman, Mesothelioma Study Committee of the National Thoracic Society between the years of 1997 and 1999.
Member of National Mesothelioma Committee, Responsible position in the planning of Nationwide treatment protocols, 2001-.Committees and Professional Experience: Meetings Attended September 1992 European Respiratory Society Annual Meeting, Vienna, Austria March 1993 4th International Conference on Home Mechanical Ventilation, Lyon, France. May 1994 Thirtieth Annual Meeting, American Society of Clinical Oncology, Dallas, USA. September 1995 3rd International Mesothelioma Conference, Creteil, France. October 1995 Biannual Meeting, World Institute of Ecology and Cancer, European Institute of Ecology and Cancer, Bursa, Turkey. December 1995 International Workshop: Chronic Obstructive Pulmonary Disease-Current Concepts and Future Prospects, Seville, Spain. April 1996 International Forum: The Scientific Bases of Cancer Chemoprevention, and Teaching Seminar: Experimental Models for Testing Potential Chemopreventive Agents , Bologna, Italy. September 1996 European Respiratory Society Annual Meeting, Stockholm, Sweden. May 1997 4th International Mesothelioma Conference, Philadelphia, Pennsylvania, USA. June 1997 Intensive hands-on Course in Interventional Bronchoscopy, Lille, France. August 1997 8th World Conference on Lung Cancer, Dublin, Ireland. August 1997 International Course: Research Methods for promotion of Lung Health, Istanbul, Turkey. September 1997 International Workshop on the Health Effects of Chrysotile
Asbestos: Contribution of Science to Risk Management Decisions, Montreal, Quebec, Canada.September 1997 International Symposium on Geology and Environment, Istanbul, Turkey. June 1998 International Scientific Conference, on the Topic “The Safe usage of Chrysotile Asbestos”, Ivano-Frankivsk, Ukraine. September 1998 5th Central European Lung Cancer Conference, Prague, Czech Republic. September 1998 European Respiratory Society Annual Congress, Geneva, Switzerland. November 1998 European School of Oncology-Vienna Office Training Program, Vienna, Austria. April 2001 Malignant Mesothelioma Therapetic Options and Role of SV40: An Update. The University of Chicago Gleacher Center, Chicogo IL (Invited speaker). June 2001 7th Central European Lung Cancer Conference, Prague, Czech Republic, as a member of scientific committee September 2001 Eurotox 2001, 13-16 September 2001, Military Museum, Istanbul, Turkey (Invited Speaker). January 2002 ALIMTA Global Advisory Board Meeting and Global Thought Leader Summit, Cancun, Mexico. April 2002 The first symposium on nutrition, environment and cancer. Ankara, 31 March-3 April, Sheraton Hotel as Member of organizing committee and invited speaker. May 2002 2nd Heilderberg Thoracic Oncology Symposium. Diagnosis And Treatment of Pleural Mesothelioma: Current Strategies and Future Concepts.Germany (Invited speaker). Professional Experience
In 1990, I participated in Prof. Baris’s Research Study Group. Under his supervision, I studied planning and development research methods, practice, and approaches pertinent to health maintenance of patients with mesothelioma. The work covers assessment of patients, evaluating the effectiveness of various kinds of therapeutic options, and epidemiological field studies.
Between the years of 1997 and 1998, I worked with international investigators, and organized national mesothelioma panels.
In 1993, I was awarded a NATO scholarship and was accepted as a research fellow in the Department of Oncology, Boston University, and Medical Center, headed by Prof. Mc Caffrey. I studied on in-vitro drug susceptibility testing with two human mesothelioma cell lines. During the study period, I learned how to propagate cell cultures, MTT drug sensitivity tests, in addition to Western Blot Laboratory method.
I worked as a chair of the national mesothelioma study group between 1997 and 1999.
Between the years of 1990 and 1998, I personally diagnosed and treated over 70 patients with mesothelioma.
I propagated a FDA controlled phase III drug study on mesothelioma as a principal investigator between the years of 1999 and 2001 in Turkey.
Special Skills
I am experienced in the management of endobronchial therapy modalities, such as endobronchial laser application, stent insertion, and brachitherapy.
I am also experienced with the usage of the Limited Sleep Study equipment (Rapid Medilog,Oxford, UK) and CPAP/BIPAP systems (Respironics Inc.,USA)
MEMBERSHIP Turkish Thoracic Society ( Former Chief of the Pleural Malignant Diseases Study Group) Globalink and FCA European Medical Assocation
Smoking or HealthThe International Association for the Study of Lung Cancer Advisory Board of National Respiratory Disease Journal Advisory Board of Journal of the International association for the Study of Lung Cancer (Lung Cancer) PUBLICATIONS
Articles:
- Tasdemir I, Turgan Ç, Emri S, Yasavul U, Çaglar S, Bakkaloglu M, Erkan I, and Erol D. Spontaneous peritoneal haematoma secondary to polyarteritis nodosa. Br J Urol 1988; 62, 219-222.
- Tasdemir I, Sivri B, Turgan Ç, Emri S, Yasavul U, and Çaglar S. The expanding spectrum of a disease. Behçet’s disease associated with amyloidosis. Nephron 1989; 52: 154-157.
- Emri S, Kalyoncu F, Demircin M, Erzen C, Sahin AA, and Baris YI. A tymic cyst with transient and spontaneous regression and false-positive cytology. JMI 1989; 18-21.
- Baris B, Emri S, Kalyoncu F. Tuberculosis of the tonsils. Hacettepe Med J 1989; 22: 135-138.
- Baris YI, Çöplü L, Selçuk ZT, Emri S, and Sahin AA. Mesothelioma due to environmental exposure to erionite in two anatolian villages in Turkey. WHO regional publication European series No. 19. Copenhagen, 1991; 149-155.
- Emri S, Çöplü L, Selçuk ZT, Sahin AA, Baris YI. Hypertrophic pulmonary osteoarthropaty in a patient with pulmonary microlithiasis. Thorax 1991; 46: 145-146.
- Emri S, BarisB, Kalyoncu F, Çopur AS, Sahin AA and Baris YI. Thymoma associated with leucopenia hypergammaglobulinemia and leucocytoclastic vasculitis. Eur J Int Med 1991; 2: 9-11.
- Kalyoncu AF, Selçuk ZT, Emri AS, Çöplü L, Sahin AA, Baris YI. Echinococcosis in the Middle East and Turkey (Letter to the editor). RID 1991; 13: 1028-1029.
- Kalyoncu AF, Çöplü L, Emri AS. Indiscriminate prescribing of NSAID’s (Letter to the editor). NZ Med J 1991; 11: 388.
- Çöplü L, Emri S, Selçuk ZT, Kalyoncu F, Balkancı F, Sahin AA, Baris YI. Life threatening chylous pleural and pericardial effusion in a patient with Behçet’s syndrome. Thorax 1992; 47: 64-65.
- Selçuk ZT, Çöplü L, Emri S, Kalyoncu AF, Sahin AA, Baris YI. Malignant pleural mesothelioma due to environmental mineral fiber exposure in Turkey. Analysis of 135 cases. Chest 1992; 102: 790-796.
- Akhan O, Demirkazik, FB,Ozmen MN, Balkancı F, Ozkara S, Çöplü L,Emri S, and Besim A. Tuberculous pleural effusions: Ultrasonic diagnosis. J Clin Ultrasound 1992; 20: 461-465.
- Kalyoncu AF, Selçuk ZT, Iskendarani A, Çöplü L, Emri S, Sahin AA, and Baris YI. Alternative and complementary medicine for asthma (Letter to the editor). Thorax 1992; 47: 762.
- Sahin AA, Çöplü L, Selçuk ZT , Eryilmaz M, Emri S, Akhan O, Baris YI. Malignant pleural mesothelioma caused by environmental exposure to asbestos or erionite in rural Turkey: CT findings in 84 patients. AJR 1993; 11: 533-537.
- Sahin AA, Selçuk ZT, Kalyoncu AF, Çöplü L, Emri S, and Baris YI. Treatment of echinococcus granulosus cysts (Letter to the editor). Scand J Infect Dis 1993; 25: 269.
- Tansan T, Emri S, Selçuk T, Koc Y, Hesketh P, Heeren T, McCaffrey RP, Baris YI. Treatment of Malignant Pleural Mesothelioma with Cisplatin, Mitomycin C and Alpha Interferon. Oncology 1994; 51: 348-351.
- Vuyst P, Dumortier P, Jacobovitz D, Emri S,Çöplü L, Baris YI. Environmental asbestosis complicated by lung cancer. Chest 1994; 105: 1593-1595.
- Kalyoncu AF, Selçuk ZT, Karakoca Y, Emri AS, Çöplü L, Sahin AA, Baris YI. Prevalence of childhood asthma and allergic disease in Ankara. Allergy 1994; 49: 485-488.
- Baris B, Emri S, Kutlu O, Kayalı Z, and Baris YI. Outbreaks of carbon monoxide poisoning in Ankara. Indoor Environ 1994; 3: 156-158.
- Idell S, Pueblitz S, Emri S, Güngen Y, Gray L, Kumar A, Holiday D, Koenig KB, and Johnson AR. Regulation of Fibrin Deposition by Malignant Mesothelioma. Am J Pathol 1995; 147: 1318-1329.
- Emri S, Baris B, Lheureux P, Leduc D, Yskenderany A, Seber O, and Baris YI. Carbon monoxide poisoning related to the use of stem coal in poorly ventilated bucket stoves. Eur J Emerg Med 1995; 2: 92-95.
- Kalyoncu AF, Çöplü L, Selçuk ZT, Emri AS, Kolaçan B, Kocabas A, Akkoçlu A, Erkan L, Sahin AA, and Baris YI. Survey on the allerjik status of patients with bronchial asthma in Turkey: A multicenter study. Allergy 1995; 50: 451-455.
- Shetty S, Kumar A, Pueblitz S, Emri S, Gungen Y, Johnson AR, and Idell S. Fibrinogen Promotes Adhesion of Monocytic to Human Mesothelioma Cells. Thromb Haemost 1996; 75: 782-790.
- Emri S, Karakoca Y, Baris YI, Zorlu F, Akyol F, and Akay H. Preventive irradiation after invasive diagnostic and therapeutic procedures in malignant pleural mesothelioma (Letter to the editor). Chest 1996; 109: 1665-1666.
- Ozdemir O, Emri S, Karakoca Y, Sayınalp N, Akay H, Dündar S, and Baris I. Fibrinolytic System in Plasma and Pleural Fluid in Malignant Pleural Mesothelioma.
- Emri S, Bagci T, Karakoca Y. Cigarette smoking habits among primary school children in Turkey. Chest 1997;112: 863-864.
- Emri S. New legislation in Turkey. Tobacco Control 1997; 6: 61.
- Karakoca Y, Emri S, Cangir AK, Baris YI. Environmental pleural plaques due to asbestos and fibrous zeolite exposure in Turkey. Indoor Built Environ 1997; 6: 100-105.
- Usalan C, Emri S. Membranoproliferative glomerulonephritis associated with small cell lung carcinoma. International Urology and Nephrology 1998; 30:209-213.
- Emri S, Ustundag Y, Budak T, Karakoca Y, Ozdemir O. Assessment of the value of fibronectin as a tumor marker in malignant pleural mesothelioma. Monaldi Archives for Chest Disease 1997, 52: 335-338.
- Karakoca Y, Emri S, Bagci T, Demir A, Erdem Y, Baris E, Sahin AA. Environmentally-induced malignant pleural mesothelioma and HLA distribution in Turkey. Int J Tuberc Lung Dis. 1998 Dec;2(12):1017-22.
- Ustündag Y, Emri S, Bayraktar Y. Superior vena cava thrombosis and obstructive sleep apnea in a patient with familian mediteranean fever. Am J Med Sci. 1998 Jul;316(1):53-5.
- Kostakoglu L, Kıratlı P, Ruacan S, Hayran M, Emri S, Ergün EL, Bekdik CF. Association of tumor washout rates and accumulation of technetium-99m-MIBI with expression of P-glycoprotein in lung cancer. J Nucl Med 1988; 39: 228-234.
- Dumortier P, Coplu L, de Maertelaer V, Emri S, Baris I, De Vuyst P. Assessment of environmental asbestos exposure in Turkey by bronchoalveolar lavage.Am J Respir Crit Care Med. 1998 Dec;158(6):1815-24.
- Emri S, Bagci T, Karakoca Y, Baris E. Recognition of cigarette brand names and logos by primary schoolchildren in Ankara, Turkey.Tob Control. 1998 Winter;7(4):386-92.
- Ustundag Y, Oksuzoglu G, Tatar G, Emri S, Kalyoncu F. Atopy and food allergy in varioliform gastritis J Clin Gastroenterol. 1998 Oct;27(3):275-6.
- Selcuk ZT, Emri S, Sahin AA, Baris YI, Coplu L, Kalyoncu F, Artvinli M. Malignant mesothelioma and erionite exposu Eur Respir J. 1999 Aug;14(2):480-1.
- Usalan C, Emri S.Exertional dyspnoea and nonproductive cough in a 22-year-old man.Postgrad Med J. 2000 Feb;76(892):115-7.
- Atimtay AT, Emri S, Bagci T, Demir AU.Urban CO exposure and its health effects on traffic policemen in Ankara.Environ Res. 2000 Mar;82(3):222-30.
- Caglar M, Ergun E, Emri S. 99Tcm-MAA lung scintigraphy in patients with Behcet's disease: its value and correlation with clinical course and other diagnostic modalities.Nucl Med Commun. 2000 Feb;21(2):171-9.
- Emri S, Kocagoz T, Olut A, Gungen Y, Mutti L, Baris YI. Simian virus 40 is not a cofactor in the pathogenesis of environmentally induced malignant pleural mesothelioma in Turkey.Anticancer Res. 2000 Mar-Apr;20(2A):891-4.
- Aydin M, Emri S, Caner B.Tc-99m pertechnetate scintigraphy before and after potassium perchlorate administration for the diagnosis of retrosternal goiter. Clin Nucl Med. 2000 Jun;25(6):467-8.
- Olut AI, Ertugrul DT, Kocagoz T, Er M,Emri S. HHV-8 is not a cofactor in the pathogenesis of environmentally induced malignant pleura mesothelioma. Monaldi Arch Chest Dis. 2000 Apr;55(2):110-3.
- Jasani B, Cristaudo A, Emri SA, Gazdar AF, Gibbs A, Krynska B, Miller C, Mutti L, Radu C, Tognon M, Procopio A. Association of SV40 with human tumours. Semin Cancer Biol. 2001 Feb;11(1):49-61. Review.
- Dumortier P, Coplu L, Broucke I, Emri S, Selcuk T, de Maertelaer V, De Vuyst P, Baris I.Erionite bodies and fibres in bronchoalveolar lavage fluid (BALF) of residents from Tuzkoy, Cappadocia, Turkey. Occup Environ Med. 2001 Apr;58(4):261-6.
- Roushdy-Hammady I, Siegel J, Emri S, Testa JR, Carbone M. Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey. Lancet. 2001 Feb 10;357(9254):444-5.
- Fani Bozkurt M, Basaran Demirkazik F, Emri S, Caner B. Ventilation-perfusion lung scan and helical computed tomographic findings in a patient with behcet's disease. Clin Nucl Med. 2001 Aug;26(8):721-2.
- Ozer N, Shehu V, Aytemir K, Ovunc K, Emri S, Kes S. Echocardiographic findings of pericardial involvement in patients with malignant pleural mesothelioma with a history of environmental exposure to asbestos and erionite. Respirology. 2000 Dec;5(4):333-6.
- Olut A, Firat P, Ertugrul D, Gungen Y, Emri S. Ras oncoprotein expression in erionite - and asbestos-induced Turkish malignancy pleural mesothelioma-a pilot study. Respiratory Medicine 2001; 95: 697-698.
- Emri S, Akbulut H, Zorlu F, Dinçol D, Akay H, Güngen Y, Icli F. Prognostic significance of flow cytometric DNA analysis in patients with malignant pleural mesothelioma. Lung Cancer. 2001(impress).
- Emri S, Demir A, Dogan M, Akay H, Bozkurt B, Carbone M, Baris I. Lung diseases due to environmental exposures to erionite and asbestos in Turkey. Toxicology Letters. 2002;127/1-3: 251-257. Review.
- Dogan AU, Baris YI, Emri S, Testa JR, Carbone M. Familial malignant mesothelioma (authors'reply). Lancet. 2001; 358: 1813-1814.
- Ariyurek MO, Karçaaltinbaca M, Demirkazik FB, Akay H, Gedikoglu G, Emri S. Bilateral multiple pulmonary tuberculous nodules mimicking metastatic disease. European Journal of Radiology. Inpress.
International Congress Abstracts:
- Baris I, Tansan S, coplu L, Hesketh P, Selcuk T, Mc Caffrey R, Emri S, Sahin A, and Bernal S. Malignant mesothelioma related to erionite exposure in Central Turkey. Proc Am Soc Clin Oncol 1991; 13: 132.
- Coplu L, Selcuk ZT, Yilmaz AS, Kalyoncu AF, Emri AS, Sahin AA, and Baris YI. Pulmonary semptoms and function in tea workers. Eur Respir J 1992; 5(suppl 15): 247s.
- Emri S, Selcuk ZT, Coplu L, Kalyoncu AF, Sahin AA, and Baris YI. Clustering of patients of unintented carbon monoxide poisoning following use of steam coal in poorly vented bucket stoves in Ankara. Eur Respir J 1992; 5(suppl 15): 249s.
- Sahin AA, Coplu L, Selcuk ZT, Eryilmaz M, Emri S, Akhan O, and Baris YI. Computed tomography findings in environmental malignant pleural mesothelioma. Eur Respir J 1993; 6(suppl 17):163s.
- Tansan S, Emri S, Coplu L, Koc Y, and Baris YI. Cisplatin (CDDP), Mitomycin-C(MMC), and alpha interferon (IFN-A) in malignant pleural mesothelioma (MPM). Eur Respir J 1993; 6(suppl 17): 288s.
- Baris B, Coplu L, Emri S, and Karakoca Y. Erionite-related non-mesotheliomal malignancies in Turkey. Eur Respir J 1993; 6(suppl 17): 487s.
- Akhan O, Boyvat F, Emri S, Ozmen M, Coplu L, Ariyurek M, Eryilmaz M, and Baris I. CT classification of pulmonary hydatid disease. Eur Respir J 1993; 6(suppl 17): 557s.
- Dumortier P, Coplu L, Selcuk ZT, Emri S, Sahin AA, Vuyst PD, and Baris YI. Fiber burden in bronchoalveolar lavage (BAL) of subjects with environmental exposures. Eur Respir J 1994; 7(suppl 18): 425s.
- Emri S, Koç Y, O’brien MC, Sanders D, Tansan S, and Foss F. Taxol and arginine butyrate exert additive and anti-proliferativ effets on human mesothelioma cells. Proc Am Soc Clin Oncol 1994; 13: 130 (abstr 316)
- Budak T, Ozdemir O, Emri S, Kalyoncu AF, Çöplü L and Baris YI. Fibronectin is unsuitable as a tumor marker in pleural mesothelioma (MPM). Chest 1994; 106(suppl 2): 96s.
- Ustundag Y, Emri S,Çaglar M, ozcebe O, Karakoca Y, Kalyoncu AF, Balkanci F, Dündar S, Seber O, and Baris YI. Assessment of pulmonary involvement in Behçet’s disease.Eur Respir J 1995; 8(suppl 19): 229s.
- Cila A, Emri S, Akhan O, Findik S, Çöplü L, Sahin A, and Baris YI. MR imaging versus CT in staging of environmental malignant pleural mesothelioma. Eur Respir J 1995; 8(suppl 19): 370s.
- Çöplü L, Kalyoncu AF, Karakoca Y, Çöplü N, Emri S, Sahin AA, and Baris YI. Respiratory disorders in paper factory workers exposed to mixture of reed and straw dust. Eur Respir J 1995; 8(suppl 19): 109s.
- Karakoca Y, Emri S, SaraçbaII O, Yasavul U, Çöplü L, Kalyoncu F, Sahin AA, and Baris YI. The relationship between HLA antigens and malignant mesothelioma. Eur Respir J 1995; 8(suppl 19): 479s.
- Emri S, Ozdemir O, Karakoca Y, Çöplü L, Dündar S, Baris I. Plasma and pleural fluid analysis of fibrinolytic system in malignant pleural mesothelioma. Third International Mesothelioma Conference, 12-15 September 1995. Creteil-Paris, France.
- Çöplü L, Demir AU, Karakoca Y, Baris B, Emri S, Sahin AA, and Baris YI. Mesothelioma and other malignancies due to erionite exposure.Third International Mesothelioma Conference, 12-15 September 1995. Creteil-Paris, France.
- Emri S, Koç Y, MC O’brien, Tansan S, Sanders D, Foss F. Antiproliferative effects of arginine butyrate in combination with taxol on two human malignant pleural mesothelioma cell lines. World Institue of Ecology and Cancer, Biannual Meeting, 6-8 October 1995, Bursa, Turkey.
- Demir AU, Çöplü L, Karakoca Y, Emri S, Baris YI. Mesotheliomal and non-mesotheliomal malignancies due to erionite exposure in Turkey. World Institue of Ecology and Cancer, Biannual Meeting, 6-8 October 1995, Bursa, Turkey.
- Emri S, Ozyigit G, BagcI T, Selçuk T, Demir A, Sahin A, and Baris YI. Recognition of cigarette brand names and logos by primary school children in Ankara. Eur Respir J 1996; 9(suppl 23): 260s.
- Karakoca Y, Emri S, Cangir AK, Er M, Findik S, and Baris YI. Environmental pleural plaques due to asbestos and fibrous zeolite exposure in Turkey. Eur Respir J 1997; 10(suppl 25): 20s.
- Emri S, Akbulut H, Dinçol D, Akay H, Güngen Y, Karakoca Y, Içli F, Zorlu F. Prognostic significance of flow cytometric DNA analysis in patients with malignant pleural mesothelioma. Accepted in 17th UICC International Cancer Congress.
- Coplu L, Emri S,Selcuk ZT, Bagcy AT, Fyndyk S, Kalyoncu F. The prevelances of cigarette smoking among the medical school students of Hacettepe University in Ankara. Eur Respir J 1998; 12 (suppl 28): 80s.
- Köksal AS,Emri S, Üsküdar O. Effect of nicotine replacement therapy in quitting in a hospital base clinic of Türkiye. Eur Respir J 1999; 14(suppl 30): 75s.
- İnce ID, Dolunay N, Savcı S, Emri S, Arıkan H. Health related quality of life in patients with chronic obstructive pulmonary diseases. Eur Respir J 1999; 14(suppl 30): 382s.
- Bilir N, Emri S, Yıldız Ani Demir A. Domestic exposure to biomass smoke and COPD prevalence among women in Turkey. Eur Respir J 1999; 14(suppl 30): 485s.
- Emri S. Lung diseases due to environmental exposure to erionite and asbestos in Turkey. Toxicology Letters 2001 123 (suppl 1): 11s.
BOOK CHAPTER:
1. Barış Yİ, Çöplü L, Selçuk ZT, Emri S, Şahin AA. Erionite-related diseases. Sluyser M (ed). Asbestos-Related Cancer, London, Ellis Horwood,1991, pp 256-275.
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